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Antibody-Dependent Cell Cytotoxicity

ADCC | Cytotoxicity, Antibody-Dependent Cell | Cell Cytoxicity, Antibody-Dependent | Antibody Dependent Cell Cytotoxicity | Antibody-Dependent Cell Cytotoxicities | Antibody-Dependent Cell Cytoxicities | Antibody-Dependent Cell Cytoxicity

The phenomenon of antibody-mediated target cell destruction by non-sensitized effector cells. The identity of the target cell varies, but it must possess surface IMMUNOGLOBULIN G whose Fc portion is intact. The effector cell is a "killer" cell possessing Fc receptors. It may be a lymphocyte lacking conventional B- or T-cell markers, or a monocyte, macrophage, or polynuclear leukocyte, depending on the identity of the target cell. The reaction is complement-independent.

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