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| Subacute Sclerosing Panencephalitis Leukoencephalitis, Subacute Sclerosing | Measles Inclusion Body Encephalitis | Panencephalitis, Subacute Sclerosing | SSPE | Van Bogaert' | s Leukoencephalitis | Encephaltis, Inclusion Body, Measles | Inclusion Body Encephalitis, Measles A rare, slowly progressive encephalitis caused by chronic infection with the MEASLES VIRUS. The condition occurs primarily in children and young adults, approximately 2-8 years after the initial infection. A gradual decline in intellectual abilities and behavioral alterations are followed by progressive MYOCLONUS; MUSCLE SPASTICITY; SEIZURES; DEMENTIA; autonomic dysfunction; and ATAXIA. DEATH usually occurs 1-3 years after disease onset. Pathologic features include perivascular cuffing, eosinophilic cytoplasmic inclusions, neurophagia, and fibrous gliosis. It is caused by the SSPE virus, which is a defective variant of MEASLES VIRUS. (From Adams et al., Principles of Neurology, 6th ed, pp767-8) | |
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