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| Striatonigral Degeneration Striatonigral Atrophy | Atrophies, Striatonigral | Atrophy, Striatonigral | Degeneration, Striatonigral | Striatonigral Atrophies | Striatonigral Degenerations A sporadic neurodegenerative disease with onset in middle-age characterized clinically by Parkinsonian features (e.g., MUSCLE RIGIDITY; HYPOKINESIA; stooped posture) and HYPOTENSION. This condition is considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Pathologic features include a prominent loss of neurons in the zona compacta of the SUBSTANTIA NIGRA and PUTAMEN. (From Adams et al., Principles of Neurology, 6th ed, p1075-6) | |
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