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| Sirtuins Sir2-like Proteins | NAD-Dependent Protein Deacetylases | Silent Mating Type Information Regulator 2-like Proteins | Sir2-like Deacetylases | Deacetylases, NAD-Dependent Protein | Deacetylases, Sir2-like | NAD Dependent Protein Deacetylases A homologous family of proteins that includes the NAD-dependent protein deacetylases which deacetylate proteins by catalyzing the formation of O-acetyl-ADP-ribose from the ADP-RIBOSE moiety (of NAD) and the acetyl group that is being removed from the protein. Sir2p, from Saccharomyces cerevisiae, is the founding member and the family includes other homologs (HSTs - homologs of Sir Two). Some HISTONE DEACETYLASES (the Sir2-like HDACs) belong to this family of proteins. | |
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