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RNA 5' Terminal Oligopyrimidine Sequence
5' | TOP Messenger RNA | 5' | TOP Sequence | 5' | TOP mRNA | RNA 5' | Terminal Oligopyrimidine Regulatory Sequence | 5' | TOP Sequences | Sequence, 5' | TOP | Sequences, 5' | TOP
A regulatory sequence found in the 5' terminal regions of a variety of RNA species. The sequence starts with a CYTIDINE, which is followed by a stretch of 5 to 15 PYRIMIDINE NUCLEOTIDES. Messenger RNA that contains the 5' Terminal OligoPyrimidine tract is often referred to as 5' TOP mRNA. The sequence acts as a translational regulator and has been found in mRNAs for PEPTIDE ELONGATION FACTORS and RIBOSOMAL PROTEINS. |
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Ribosomal Protein S6
Protein S6, Ribosomal
A ribosomal protein that may play a role in controlling cell growth and proliferation. It is a major substrate of RIBOSOMAL PROTEIN S6 KINASES and plays a role in regulating the translation (TRANSLATION, GENETIC) of RNAs that contain an RNA 5' TERMINAL OLIGOPYRIMIDINE SEQUENCE. |
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Terminal Repeat Sequences
Delta Elements | Flanking Repeat Sequences | Inverted Terminal Repeat | Long Terminal Repeat | R Repetitive Sequence | Terminal Repeat | Delta Element | Element, Delta | Elements, Delta | Flanking Repeat Sequence | Long Terminal Repeats
Nucleotide sequences repeated on both the 5' and 3' ends of a sequence under consideration. For example, the hallmarks of a transposon are that it is flanked by inverted repeats on each end and the inverted repeats are flanked by direct repeats. The Delta element of Ty retrotransposons and LTRs (long terminal repeats) are examples of this concept. |
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Procollagen
Protocollagen | Procollagen Type M
A biosynthetic precursor of collagen containing additional amino acid sequences at the amino-terminal and carboxyl-terminal ends of the polypeptide chains. |
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Repetitive Sequences, Nucleic Acid
DNA Repetitious Region | Direct Repeat | Genes, Selfish | Inverted Repeat Sequence | Nucleic Acid Repetitive Sequences | Repetitive Region | Selfish Genes | Repetitious Region, DNA | Repetitive Sequence | DNA Repetitious Regions | Direct Repeats
Nucleotide sequences present in multiple copies in the genome. There are several types of repeated sequences. Interspersed (or dispersed) DNA repeats (INTERSPERSED REPETITIVE SEQUENCES) are copies of transposable elements interspersed throughout the genome. Flanking (or terminal) repeats (TERMINAL REPEAT SEQUENCES) are sequences that are repeated on both ends of a sequence, for example, the long terminal repeats (LTRs) on retroviruses. Direct terminal repeats are in the same direction and inverted terminal repeats are opposite to each other in direction. Tandem repeats (TANDEM REPEAT SEQUENCES) are repeated copies which lie adjacent to each other. These can also be direct or inverted. The ribosomal RNA and transfer RNA genes belong to the class of middle repetitive DNA. |
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Sequence Analysis
Sequence Determination | Analysis, Sequence | Determination, Sequence | Determinations, Sequence | Sequence Determinations | Analyses, Sequence | Sequence Analyses
A multistage process that includes the determination of a sequence (protein, carbohydrate, etc.), its fragmentation and analysis, and the interpretation of the resulting sequence information. |
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Sequence Tagged Sites
Sequence-Tagged Sites | Sequence Tagged Site | Sequence-Tagged Site | Site, Sequence Tagged | Site, Sequence-Tagged | Sites, Sequence Tagged | Sites, Sequence-Tagged | Tagged Site, Sequence | Tagged Sites, Sequence
Short, tagged tracts of DNA sequence that are used as landmarks in GENOME mapping. In most instances, 200 to 500 base pairs of sequence define a Sequence Tagged Site (STS) that is operationally unique in the human genome (i.e., can be specifically detected by the polymerase chain reaction in the presence of all other genomic sequences). The overwhelming advantage of STSs over mapping landmarks defined in other ways is that the means of testing for the presence of a particular STS can be completely described as information in a database. |
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Sequence Analysis, DNA
DNA Sequence Analysis | Sequence Determination, DNA | Analysis, DNA Sequence | DNA Sequence Determination | DNA Sequence Determinations | Determination, DNA Sequence | Determinations, DNA Sequence | Sequence Determinations, DNA
A multistage process that includes DNA cloning, physical mapping, subcloning, sequencing, and information analysis. |
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Sequence Analysis, RNA
RNA Sequence Analysis | Sequence Determination, RNA | Analysis, RNA Sequence | Determination, RNA Sequence | Determinations, RNA Sequence | RNA Sequence Determination | RNA Sequence Determinations | Sequence Determinations, RNA
A multistage process that includes RNA cloning, physical mapping, subcloning, sequencing, and information analysis. |
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Sequence Alignment
Sequence Homology Determination | Determination, Sequence Homology | Alignment, Sequence | Alignments, Sequence | Determinations, Sequence Homology | Sequence Alignments | Sequence Homology Determinations
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms. |
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