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| Integrins Cell-Adhesion Molecule Receptors | Receptors, Cell-Adhesion Protein | Cell-Adhesion Molecule Receptor | Cell-Adhesion Protein Receptor | Cell-Adhesion Protein Receptors | Receptor, Cell-Adhesion Molecule | Receptor, Cell-Adhesion Protein A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development, HEMOSTASIS, THROMBOSIS, WOUND HEALING, immune and nonimmune defense mechanisms, and oncogenic transformation. | |
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