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Fibrinogen

Coagulation Factor I | Factor I | Blood Coagulation Factor I | gamma-Fibrinogen | Factor I, Coagulation | I, Coagulation Factor | gamma Fibrinogen

Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.

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