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Nonsuppressible Insulin-Like Activity

NSILA | NSILA-P | NSILA-S | Nonsuppressible Insulinlike Activity | Activity, Nonsuppressible Insulin-Like | Activity, Nonsuppressible Insulinlike | Insulin-Like Activity, Nonsuppressible | Insulinlike Activity, Nonsuppressible

A blood protein (NSILA) which mimics the biological activity of insulin in serum, but is not suppressed by insulin antibodies. During acid-ethanol extraction of Cohn fraction III, 10% of the activity is found in the supernatant (NSILA-S) and the remaining activity in the precipitate (NSILA-P). The latter is a large molecular compound, much less stable than the soluble fraction. NSILA-S is a more potent growth factor than insulin and exhibits sulfation activity.
 
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