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| Kidney Failure, Chronic ESRD | End-Stage Renal Disease | Kidney Insufficiency, Chronic | Renal Disease, End-Stage | Renal Failure, Chronic | Renal Failure, End-Stage | Renal Insufficiency, Chronic | End-Stage Kidney Disease | Chronic Kidney Failure An irreversible and usually progressive reduction in renal function in which both kidneys have been damaged by a variety of diseases to the extent that they are unable to adequately remove the metabolic products from the blood and regulate the body's electrolyte composition and acid-base balance. Chronic kidney failure requires HEMODIALYSIS or surgery, usually KIDNEY TRANSPLANTATION. |