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| Isocitrate Dehydrogenase NAD Isocitrate Dehydrogenase | Isocitrate Dehydrogenase (NAD+) | Isocitrate Dehydrogenase-I | Dehydrogenase, Isocitrate | Dehydrogenase, NAD Isocitrate | Isocitrate Dehydrogenase I | Isocitrate Dehydrogenase, NAD An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (From Dorland, 27th ed) (The NADP+ enzyme is EC 1.1.1.42.) EC 1.1.1.41. |