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| DNA Topoisomerases Topoisomerases, DNA Enzymes that regulate the topology of DNA by actions such as breaking, relaxing, passing, and rejoining strands of DNA in cells. These enzymes are important components of the DNA replication system. They are classified by their substrate specificities. DNA TOPOISOMERASE, TYPE I enzymes act on a single strand of DNA. DNA TOPOISOMERASE, TYPE II enzymes act on double strands of DNA. |