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| RGS Proteins Regulators of G-Protein Signaling Proteins | RGS Protein (G-Protein Signaling) | Regulators of G Protein Signaling Proteins A large family of evolutionarily conserved proteins that function as negative regulators of HETEROTRIMERIC GTP-BINDING PROTEINS. RGS PROTEINS act by increasing the GTPase activity of the G alpha subunit of a heterotrimeric GTP-binding protein, causing it to revert to its inactive (GDP-bound) form. |