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| Kininogen, High-Molecular-Weight High-Molecular-Weight Kininogen | Fitzgerald Factor | HMWK | High Molecular Weight Kininogen | High Molecular Weight Kininogens | High-Molecular-Weight Kininogens | Kininogens, High Molecular Weight | Kininogen, High Molecular Weight A plasma protein, molecular weight of 110 kD, that normally exists in plasma in a 1:1 complex with PREKALLIKREIN. HMWK is split by plasma kallikrein to produce BRADYKININ. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to KALLIKREINS. (From Stedman, 26th ed) |