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| Multiple System Atrophy Multiple System Atrophy Syndrome | Multisystem Atrophy | Multisystemic Atrophy | Atrophies, Multisystem | Atrophies, Multisystemic | Atrophy, Multiple System | Atrophy, Multisystem | Atrophy, Multisystemic | Multiple System Atrophies A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92) |