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| Aphasia, Primary Progressive Mesulam Syndrome | Progressive Nonfluent Aphasia | Mesulam' | s Syndrome | Aphasia, Progressive Nonfluent | Aphasias, Primary Progressive | Aphasias, Progressive Nonfluent | Nonfluent Aphasia, Progressive | Nonfluent Aphasias, Progressive A progressive form of dementia characterized by the global loss of language abilities and initial preservation of other cognitive functions. Fluent and nonfluent subtypes have been described. Eventually a pattern of global cognitive dysfunction, similar to ALZHEIMER DISEASE, emerges. Pathologically, there are no Alzheimer or PICK DISEASE like changes, however, spongiform changes of cortical layers II and III are present in the TEMPORAL LOBE and FRONTAL LOBE. (From Brain 1998 Jan;121(Pt 1):115-26) |