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| Multiple Endocrine Neoplasia Type 2a MEN 2 | MEN 2a | Neoplasia, Multiple Endocrine Type 2a | Neoplasms, Multiple Endocrine Type 2a | Sipple Syndrome | MEA 2a | MEA II | MEA IIa | MEN II | MEN IIa | MEN2a | Multiple Endocrine Neoplasms Type 2a A type of multiple endocrine neoplasia characterized by a virtually 100% incidence of medullary thyroid carcinoma, a 50% incidence of pheochromocytoma, and a lesser incidence of parathyroid adenomas associated with hyperparathyroidism. The condition is always transmitted through autosomal dominant inheritance. Genetic testing can identify individuals with the trait in early infancy. Treatment is usually excision of the enlarged parathyroid glands. (From Holland et al., Cancer Medicine, 3d ed, pp1172-75) |