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| Granulocyte-Macrophage Colony-Stimulating Factor CSF-GM | Colony-Stimulating Factor, Granulocyte-Macrophage | GM-CSF | Histamine-Producing Cell-Stimulating Factor | CSF-2 | TC-GM-CSF | Tumor-Cell Human GM Colony-Stimulating Factor | Cell-Stimulating Factor, Histamine-Producing An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages. |