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| Fusion Proteins, bcr-abl Oncogene Protein p190(bcr-abl) | Oncogene Protein p210(bcr-abl) | bcr-abl Fusion Proteins | Fusion Proteins, bcr abl | Proteins, bcr-abl Fusion | bcr abl Fusion Proteins Translation products of a fusion mRNA derived from the breakpoint cluster region (bcr) gene and a cellular abl (c-abl) gene translocated to chromosome 22. The p210(bcr-abl) fusion protein is found in patients with chronic myelogenous leukemia. The p190(bcr-abl) fusion protein is found in patients with acute lymphocytic leukemia. The activation of human c-abl by chromosomal translocation is essentially the same as the activation of murine c-abl by viral translocation in Abelson murine leukemia virus. |