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| Factor VIIIa Coagulation Factor VIIIa | Factor VIII, Activated | Factor VIII, Thrombin-Activated | Blood Coagulation Factor VIII, Activated | Activated Factor VIII | Factor VIII, Thrombin Activated | Factor VIIIa, Coagulation | VIIIa, Coagulation Factor Activated form of factor VIII. The B-domain of factor VIII is proteolytically cleaved by thrombin to form factor VIIIa. Factor VIIIa exists as a non-covalent dimer in a metal-linked (probably calcium) complex and functions as a cofactor in the enzymatic activation of factor X by factor IXa. Factor VIIIa is similiar in structure and generation to factor Va. |