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| Giant Cells, Langhans Langhans Giant Cells | Langhans-Type Giant Cells | Cells, Langhans Giant | Cells, Langhans-Type Giant | Giant Cells, Langhans-Type | Langhans Type Giant Cells Multinucleated cells (fused macrophages) seen in granulomatous inflammations such as tuberculosis, syphilis, sarcoidosis, and deep fungal infections. They resemble foreign-body giant cells (GIANT CELLS, FOREIGN BODY) but Langhans giant cells contain less chromatin and their nuclei are arranged peripherally in a horseshoe-shaped pattern. Langhans giant cells occur frequently in delayed hypersensitivity. |