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| Osteocalcin Bone Gla Protein | Calcium-Binding Protein, Vitamin K-Dependent | Gla Protein, Bone | Vitamin K-Dependent Bone Protein | 4-Carboxyglutamic Protein, Bone | Bone gamma-Carboxyglutamic Acid Protein | 4 Carboxyglutamic Protein, Bone Vitamin K-dependent calcium-binding protein synthesized by osteoblasts and found primarily in bone. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of calcium, promotes binding to hydroxyapatite and subsequent accumulation in bone matrix. |