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| CD4-Positive T-Lymphocytes T4 Cells | T4 Lymphocytes | CD4-Positive Lymphocytes | CD4 Positive T Lymphocytes | CD4-Positive Lymphocyte | CD4-Positive T-Lymphocyte | Lymphocyte, CD4-Positive | Lymphocytes, CD4-Positive | T-Lymphocyte, CD4-Positive | T4 Cell | T4 Lymphocyte A critical subpopulation of regulatory T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes, which includes both the helper-inducer (T-LYMPHOCYTES, HELPER-INDUCER) and suppressor-inducer (T-LYMPHOCYTES, SUPPRESSOR-INDUCER) T-cells. |