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| T-Lymphocytes, Cytotoxic Cell-Mediated Lympholytic Cells | Cytotoxic T-Lymphocytes | TC1 Cells | TC2 Cells | Cell Mediated Lympholytic Cells | Cell, Cell-Mediated Lympholytic | Cell, TC1 | Cell, TC2 | Cell-Mediated Lympholytic Cell | Cells, Cell-Mediated Lympholytic Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from natural killer cells (KILLER CELLS, NATURAL) and from KILLER CELLS mediating antibody-dependent cell cytotoxicity. There are two effector phenotypes: TC1 and TC2. |